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2016年WHO 中枢神经系统肿瘤分类

2016 WHO classification of tumours of the central nervous system

2016WHO 中枢神经系统肿瘤分类

 

Diffuse astrocytic and oligodendroglial tumours

弥漫性星形和少突胶质细胞肿瘤

Diffuse astrocytoma, ID-mutant

弥漫性星形细胞瘤,IDH—突变型

Gemistocytic astrocytoma, IDH-mutant

肥胖型星形细胞瘤,IDH—突变型

Diffuse astrocytoma, IDH-wildtype

弥漫性星形细胞瘤,IDH—野生型

Diffuse astrocytoma, NOS

弥漫性星形细胞瘤,未明确

 

Anaplastic astrocytoma, IDH-mutant

间变型星形细胞瘤,IDH—突变型

Anaplastic astrocytoma, IDH-wildtype

间变型星形细胞瘤,IDH—野生型

Anaplastic astrocytoma, NOS

间变型星形细胞瘤,非特指型

 

Glioblastoma, IDH-wildtype

胶质母细胞瘤,IDH—野生型    

Giant cell glioblastoma

巨细胞胶质母细胞瘤

Gliosarcoma

胶质肉瘤

Epithelioid glioblastoma

上皮样胶质母细胞瘤

Glioblastoma, IDH-mutant

胶质母细胞瘤,IDH—突变型

Glioblastoma, NOS

胶质母细胞瘤,非特指型

 

Diffuse midline glioma, H3 K27M-mutant

弥漫性中线胶质瘤,H3 K27M突变

 

Oligodendroglioma, IDH-mutant and 1p/19q-codeleted

少突胶质细胞瘤,IDH突变和1p/19q联合性缺失

Oligodendroglioma, NOS

少突胶质细胞瘤,非特指型

 

Anaplastic oligodendroglioma, IDH-mutant  and 1p/19q-codeleted

间变型少突胶质细胞瘤,IDH突变和1p/19q联合性缺失

Anaplastic oligodendroglioma, NOS

间变型少突胶质细胞瘤,非特指型

 

Oligoastrocytoma, NOS

少突星形细胞瘤,非特指型

Anaplastic oligoastrocytoma, NOS

间变型少突星形细胞瘤,非特指型

 

Other astrocytic tumours

其他星形细胞肿瘤

Pilocytic astrocytoma

毛细胞星形细胞瘤

Pilomyxoid astrocytoma

毛细胞黏液样星形细胞瘤

Subependymal giant cell astrocytoma

室管膜下巨细胞星形细胞瘤

Pleomorphic xanthoastrocytoma

多形性黄色瘤样星形细胞瘤

Anaplastic pleomorphic xanthoastrocytoma

间变型多形性黄色星形细胞瘤

 

Ependymal tumours

室管膜肿瘤

Subependymoma

室管膜下瘤

Myxopapillary ependymoma

黏液乳头型室管膜瘤

Ependymoma

室管膜瘤

Papillary ependymoma

乳头型室管膜瘤

Clear cell ependymoma

透明细胞型室管膜瘤

Tanycytic ependymoma

伸长细胞型室管膜瘤

Ependymoma, RELA fusion-positive

室管膜瘤,RELA融合阳性

Anaplastic ependymoma

间变型室管膜瘤

 

Other gliomas

其他胶质瘤

Chordoid glioma of the third ventricle

第三脑室脊索样胶质瘤

Angiocentric glioma

血管中心性胶质瘤

Astroblastoma

星形母细胞瘤

 

Choroid plexus tumours

脉络丛肿瘤

Choroid plexus papilloma

脉络丛乳头状瘤

Atypical choroid plexus papilloma

非典型脉络丛乳头状瘤

Choroid plexus carcinoma

脉络丛癌

 

Neuronal and mixed neuronal-glial tumours

神经元和混合性神经元胶质肿瘤

Dysembryoplastic neuroepithelial tumour

胚胎发育不良性神经上皮肿瘤

Gangliocytoma

节细胞瘤

Ganglioglioma

节细胞胶质瘤

Anaplastic ganglioglioma

间变性节细胞胶质瘤

Dysplastic cerebellar gangliocytoma

 (Lhermitte-Duclos disease)

小脑发育不良性节细胞瘤(Lhermitte-Duclos病)

Desmoplastic infantile astrocytoma and Ganglioglioma

婴儿促纤维增生型星形细胞瘤/节细胞胶质瘤

Papillary glioneuronal tumour

乳头状胶质神经元肿瘤

Rosette-forming glioneuronal tumour

伴菊形团形成的胶质神经元肿瘤

Diffuse leptomeningeal glioneuronal tumour

弥漫性软脑膜胶质神经元肿瘤

Central neurocytoma

中枢神经细胞瘤

Extraventricular neurocytoma

脑室外神经细胞瘤

Cerebellar liponeurocytoma

小脑脂肪神经细胞瘤   

Paraganglioma

副神经节瘤

 

Tumours of the pineal region

松果体区肿瘤

Pineocytoma

松果体细胞瘤

Pineal parenchymal tumour of intermediate differentiation

中分化松果体实质肿瘤

Pineoblastoma

松果体母细胞瘤

Papillary tumour of the pineal region

松果体区乳头状肿瘤

 

Embryonal tumours

胚胎性肿瘤

Medulloblastomas, Genetically defined

髓母细胞瘤,基因学分类

Medulloblastoma, WNT-activated

髓母细胞瘤,WNT活化

Medulloblastoma, SHH-activated and TP53-mutant

髓母细胞瘤,SHH活化和TP53突变型

Medulloblastoma, SHH-activated and TP53-wildtype

髓母细胞瘤,SHH活化和TP53野生型

Medulloblastoma, non-WNT/non-SHH

髓母细胞瘤,非WNT/SHH

Medulloblastoma, group 3

髓母细胞瘤,3

Medulloblastoma, group 4

髓母细胞瘤,4

Medulloblastomas, histologically defined

髓母细胞瘤,组织学分类

Medulloblastoma, classic

髓母细胞瘤,经典型

Medulloblastoma, desmoplastic/nodular

髓母细胞瘤,促纤维增生/结节

Medulloblastoma with extensive nodularity

髓母细胞瘤伴广泛结节形成

Medulloblastoma, large cell / anaplastic

髓母细胞瘤,大细胞/间变型

Medulloblastoma, NOS

髓母细胞瘤,非特指型

 

Embryonal tumour with multilayered rosettes, C19MC-altered

胚胎性肿瘤伴多层菊形团,C19MC改变

Embryonal tumour with multilayered rosettes, NOS

胚胎性肿瘤伴多层菊形团,非特指型

Medulloepithelioma

髓上皮瘤

CNS neuroblastoma

中枢神经系统神经母细胞瘤

CNS ganglioneuroblastoma

中枢神经系统节细胞神经母细胞瘤

CNS embryonal tumour, NOS

中枢神经系统胚胎性肿瘤,非特指型

Atypical teratoid / rhabdoid tumour

非典型胚胎样/横纹肌样肿瘤

CNS embryonal tumour with rhabdoid features

中枢神经系统胚胎性肿瘤伴有横纹肌样特征

 

Tumours of the cranial and paraspinal nerves

颅神经和椎旁神经肿瘤

Schwannoma

神经鞘瘤

Cellular schwannoma

细胞性神经鞘瘤

Plexiform schwannoma

丛状神经鞘瘤

Melanotic schwannoma

黑色素性神经鞘瘤

Neurofibroma

神经纤维瘤

Atypical neurofibroma

非典型神经纤维瘤

Plexiform neurofibroma

丛状神经纤维瘤

Perineurioma

神经束膜瘤

Hybrid nerve sheath tumours

混合性神经鞘肿瘤

Malidnant peripheral nerve sheath tumour

恶性外周神经鞘瘤(MPNST

Epithelioid MPNST

上皮型恶性外周神经鞘瘤

MPNST with perinurial differentiation

恶性外周神经鞘瘤伴神经束膜分化

 

Meningiomas

脑膜瘤

Meningioma

脑膜瘤

Meningothelial meningioma

脑膜上皮型脑膜瘤

Fibrous meningioma

纤维型脑膜瘤

Transitional meningioma

过渡型脑膜瘤

Psammomatous meningioma

砂粒体型脑膜瘤

Angiomatous meningioma

血管瘤型脑膜瘤

Microcystic meningioma

微囊型脑膜瘤

Secretory meningioma

分泌型脑膜瘤

Lymphoplasmacyte-rich meningioma

富于淋巴浆细胞型脑膜瘤

Metaplastic meningioma

化生型脑膜瘤

Chordoid meningioma

脊索样型脑膜瘤

Clear cell meningioma

透明细胞型脑膜瘤

Atypical meningioma

非典型脑膜瘤

Papillary meningioma

乳头型脑膜瘤

Rhabdoid meningioma

横纹肌样型脑膜瘤

Anaplastic (malignant) meningioma

间变型(恶性)脑膜瘤

 

Mesenchymal, non-meningothelial tumours

间叶性肿瘤,非脑膜上皮细胞来源肿瘤

Solitary fibrous tumour / haemangiopericytoma**

孤立性纤维性肿瘤/血管外周细胞瘤

Grade 1

1

Grade 2

2

Grade 3

3

Haemangioblastoma

血管母细胞瘤

Haemangioma

血管瘤

Epithelioid haemangioendothelioma

上皮样血管内皮细胞瘤

Angiosarcoma

血管肉瘤

Kapposi sarooma

卡波西肉瘤

Ewing sarcoma / PNET

尤文肉瘤/PNET

Lipoma

脂肪瘤

Angiollpoma

血管脂肪瘤

Hibernoma

冬眠瘤

Liposarcoma

脂肪肉瘤

Dermoid-type fibromatosis

韧带样型纤维瘤病

Myofibroblastoma

肌纤维母细胞瘤

Inflammatory myofibroblastic tumour

炎性肌纤维母细胞瘤

Benign fibrous histiocytoma

良性纤维组织细胞瘤

Fibrosarcoma

纤维肉瘤

Undifferentiated pleomorphic sarcoma / Manignant fibrous histiocytoma

未分化多形性肉瘤/恶性纤维组织细胞瘤

Leiomyoma

平滑肌瘤

Leiomyosarcoma

平滑肌肉瘤

Rhabdomyoma

横纹肌瘤

Rhabdomyosarcoma

横纹肌肉瘤

Chondroma

软骨瘤

Chondrosarcoma

软骨肉瘤

Osteoma

骨瘤

Osteochondroma

骨软骨瘤

Osteosarcoma

骨肉瘤

 

Melanocytic tumours

黑色素细胞肿瘤

Meningeal melanocytosis

脑膜黑色素细胞增多症

Meningeal melanocytoma

脑膜黑色素细胞瘤

Meningeal melanoma

脑膜黑色素细胞瘤

Meningeal melanomatosis

脑膜黑色素瘤病

 

Lymphomas

淋巴瘤

Diffuse large B-cell lymphoma of the CNS

中枢神经系统弥漫性大B细胞淋巴瘤

Immunodeficiency-associated CNS lymphomas

免疫缺陷相关中枢神经系统淋巴瘤

AIDS-related diffuse large B-cell lymphoma

AIDS相关性弥漫性大B细胞淋巴瘤

EBV-positive diffuse large B-cell lymphoma. NOS

EBV阳性弥漫性大B细胞淋巴瘤,非特指型

Lymphomatoid granulomatosis

淋巴瘤样肉芽肿

Intravascular large B-cell lymphoma

血管内大B细胞淋巴瘤

Low-grade B-cell lymphomas of the CNS

中枢神经系统低级别B细胞淋巴瘤

T-cell and NK / T-cell lymphomas of the CNS

中枢神经系统T/NK细胞淋巴瘤

Anaplastic large cell lymphoma, ALK-positive

间变性大细胞淋巴瘤,ALK阳性

Anaplastic large cell lymphoma, ALK-negative

间变性大细胞淋巴瘤,ALK阴性

MALT lymphoma of the dura

硬脑膜黏膜相关淋巴组织边缘区淋巴瘤

 

Histiocytic tumours

组织细胞肿瘤

Langerhans cell histiocytosis

朗格汉斯细胞组织细胞增生

Erdheim-Chester disease

Erdheim-Chester

Rosai-Dorfman disease

Rosai-Dorfman

Juvenile xanthogranuloma

幼年黄色肉芽肿

Histiocytic sarcoma

组织细胞肉瘤

 

Germ cell tumours

生殖细胞肿瘤

Germinoma

生殖细胞瘤

Embryonal carcinoma

胚胎癌

Yolk sac tumour

卵黄囊瘤

Choriocarcinoma

绒毛膜癌

Teratoma

畸胎瘤

Mature teratoma

成熟性畸胎瘤

Immature teratoma

未成熟性畸胎瘤

Teratoma with malignant transformation

畸胎瘤伴恶性转化

Mixed germ cell tumour

混合性生殖细胞肿瘤

 

Tumours of the sellar region

鞍区肿瘤

Craniopharyngioma

颅咽管瘤

Adamantinomatous craniopharyngioma

造釉细胞型颅咽管瘤

Papillary craniopharyngioma

乳头状颅咽管瘤

Granular cell tumour of the sellar region

鞍区颗粒细胞瘤

Pituicytoma

垂体细胞瘤

Spindle cell oncocytoma

梭形细胞嗜酸细胞瘤

 

Metastatic tumours

转移性肿瘤 


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